I know this isn't major, but I'd love actual unique items, and while we're at it, better-looking enchantments.
In III, IV and V, when you get a, let's say, for example, a daedric artefact that has an okay enchantment, but looks cool as hell, you'll want to use it. I used the shit out of dawnbreaker, even though I didn't much like the enchantment. when you get a weapon with a very good or unique enchantment, but has a basic texture, for example, 'gloves of the pugilist' the enchantment is unique and cool, but I'd rather disenchant them because I don't wanna walk around with fur gauntlets.
if most (or, wishful thinking, all) unique items had unique textures, you'd have a bunch of cool weapons to choose from. and while we're at it, the way enchantments look on weapons in the previous games is kinda half-assed. Instead of covering the whole weapon with a translucent texture, why not have the details of the weapon glow the colour of the enchantment? then even a crappy steel sword would look badass. this wouldn't apply to armour very well, but they're Bethesda. they could come up with something.
Edit: just realized that this forum stopped years ago. whoops.